Research into the medical applications of serotonergic psychedelics (Psilocybin, Lysergic acid diethylamide, Dimethyltryptamine) is rapidly growing. Over the last year, a surge of clinical trials have been announced testing the efficacy of psychedelics to treat a range of physical health conditions, including: lower back pain, fibromyalgia, cluster headache, phantom limb pain and cancer pain. Share prices of psychedelic pharmaceutical companies have soared, but what is the actual evidence supporting this treatment; and is there potential for broader applications, such as in musculoskeletal health or stroke rehabilitation?